A super-charged dose of hydration, our Hydrating Dew is a silicone-free, velvety créme that fights the appearance of fine lines and wrinkles while providing deep, lasting hydration.

The most powerful regenerative skincare featuring the Carmell Secretome™, a proprietary formulation of up to 1000 proteins and peptides derived from allogeneic human platelets complemented by a blend of bio-lipids, bio-hydration and vitamins/minerals/botanicals to deliver Carmell Complete Care. Free from the Foul14 (see images for additional information).

Designed for daily use.

Carmell® Hydrating Dew

• Deeply hydrates and locks in moisture without petrolatum or other pore-clogging ingredients.
• Minimizes the appearance of wrinkles and fine lines with 1000+ Growth Factors, Proteins, Peptides.
• Plumps and smooths skin with powerful emollients including Squalane, Shea Butter and 3 types of Ceramides.
• Hydrates skin with 2 types of Hyaluronic Acid and 2 types of Olivates.
• Improves skin tone with 2 types of Vitamin C, Vitamin E, and Ferulic Acid.
• Revitalizes skin NAD+ with Niacinamide.
• Banishes dark spots and hyperpigmentation with Bakuchiol and Bisabolol.

Carmell Hydrating Dew Ingredients:

• Water
• Butyrospermum Parkii (shea) Butter
• Carmell Secretome [Human Platelet Enriched Plasma]
• Squalane
• Ceramides NP/AP/EOP
• Niacinamide [Vitamin B3]
• Sodium Hyaluronate [Low Mol Wt HA]
• Sodium Hyaluronate [High Mol Wt HA]
• Tocopherol [Vitamin E]
• Bakuchiol
• Bisabolol
• Cetearyl Alcohol
• Cetearyl Olivate
• Sorbitan Olivate
• Ferulic Acid
• 3-O-Ethyl-L-Ascorbic Acid [Vitamin C]
• Tetrahexyldecyl Ascorbate [Vitamin C]
• Potassium Sorbate
• Polyisobutene
• Polysorbate 20
• Polyacrylate-13
• Glyceryl Caprylate
• Capryl Glycol
• Sodium Gluconate
• Tribehenin
• Xanthan Gum
• Citric Acid

Carmell Secretome - The Biggest Ingredients In Carmell Skin Care:

Human biology is inherently regenerative. Our bodies grow from childhood until we reach maturity. We heal from injuries and sickness. Our skin, for instance, renews itself fully every 28-60 days depending on our age and health.

Our ability to heal declines with age, sickness or chronic stress. However, we can slow and even reverse the deleterious effects of aging with supplementation and care.

Carmell’s philosophy is to use ingredients that are “Built by Biology, Just as Nature Intended” to replenish bio actives that are central to our health. We do not believe in “Hero products” that are fundamentally incomplete leaving the consumer to wade through a bewildering set of choices, mix and match products that may interact with each other adversely and may still far short of delivering quality care.

Carmell Secretome

Stem cells have a near mythical place as a tool of regenerative medicine. However, stem cells are found in almost all tissues of the body. Unlike embryonic stem cells, adult stem cells are not pluripotent and generate specific kinds of tissue. For example, stem cells found in the bone marrow give rise specifically to blood cells (red, white, and platelets).

Because blood circulates throughout our body, blood cells play a key role in keeping us alive and healthy. Red blood cells carry oxygen, white blood (immune) cells protect us from disease whereas platelets are responsible for healing.

Depending on our health, we have 150,000-450,000 circulating platelets per microliter of blood. However, platelets are not biologically active until they are activated. When platelets are activated, they break apart to release a large number of growth factors, proteins and peptides.

Carmell spent 7 years and over $60 million developing a comprehensive process to extract the Platelet Enriched Plasma secretome in a shelf-stable formula. In addition to process development, we took great care to study the safety and potency of the Carmell Secretome.

The following peer-reviewed publications provide more information:

1. Platelet Rich Plasma: a short overview of certain bioactive components
2. Platelet-Rich Plasma (PRP) in Dermatology: Cellular and Molecular Mechanisms of Action
3. Platelet-rich plasma is a promising therapy for melasma
4. Lasers, Microneedling, and Platelet-Rich Plasma for Skin Rejuvenation and Repair

Bio Lipids

Our skin is composed principally of proteins (75-80%) and lipids (5-15%). Carmell uses lipids that are part of healthy human biology:

Ceramides are the most important lipids in our skin. We use 3 kinds of ceramides in our products.

Ceramide EOP is crucial for maintaining skin hydration and promoting a smooth texture.

Ceramide NP plays a pivotal role in the skin's barrier function, preventing moisture loss and enhancing structural resilience.

Ceramide AP contributes to the structural integrity of the skin to support its ability to withstand environmental.

Squalane is a stable form of squalene (found in sebum). Squalene prevents Trans Epidermal Water Loss by creating a natural occlusive layer. It also counteracts the damaging effects of UVA exposure. Squalene levels are known to drop as we get older. Hence, topical squalane supplementation helps with skin hydration and address sun damage.

• Other skincare companies use cheap petroleum byproducts or vegetable oils such coconut or sunflower oil as emollients - these form a thick film on the skin resulting in an oily sheen and clogged pores.

Bio Hydration

Our skin's turgor, resilience and pliability is correlated with hydration. Carmell uses a combination of hydration agents based on healthy human biology:

• Low molecular weight Hyaluronic Acid penetrates into the skin to deliver deep hydration.
• High molecular weight Hyaluronic Acid stays in the upper layers of the skin to plump skin.
• Urea is being touted for its hydrating ability but its smell can be off putting. We use Allantoin, a metabolite of urea, which has powerful hygroscopic (water-loving), keratolytic (skin renewal), and antimicrobial properties.

Vitamins, Minerals, Botanicals

• Of the 14 essential vitamins required for healthy living, humans are able to synthesize only Vitamin D and B3. The remaining vitamins must be supplemented. Vitamins are key to ensuring the structural integrity of our skin, its ability to fight off infections and counteract the corrosive effects of radiation, pollution, stress and aging.
• Similarly, we need micronutrients like minerals to ensure healthy physiology. For instance, Zinc helps address chronic inflammation.
• Botanicals like bakuchiol, bisabolol and chitosan have a range of potent health benefits and are a staple of Ayurvedic, Chinese and Korean health regimens.

The Carmell Promise:

Carmell is committed to the highest ethical standards of ingredient selection and formulation.  We have created our products without the Foul14™. These 14 chemical excipients cause more harm than good to our health and are used to help create texture (creamy, slippery, etc), fragrance, or color.

Sulfates

Sulfate salts form when sulfuric acid reacts with another chemical. Sulfates, namely sodium lauryl sulfate (SLS) and sodium laureth sulfate (SLES), act as surfactants that reduce the surface tension of oil and water allowing them to spread more easily.

Reasons to banish sulfates from your beauty regimen.

Silicones

Silicones are a group of semi-liquid substances derived from silica. They are synthetic ingredients used in cosmetics for their conditioning benefits and slick feel. Silicones are hydrophobic (they repel water) and do not rinse off easily (they require and oil-based wash or double cleansing). After application, they may block subsequent ingredients from contacting the skin, rendering anything applied afterward useless.

Silicones include: dimethicone, cyclomethicone, cycloheasiloxane, cetearyl methicone and cyclopentasiloxane.

10 reasons why silicone is bad for your skin.

Silicates

Silicates are commonly found in skincare products as ingredients like silica, sodium silicate, and magnesium aluminum silicate. Some potential drawbacks associated with their presence in skincare products include:

1. Skin irritation - fine particles of silica can have a scrubbing effect and potentially lead to microtears in the skin, exacerbating irritation.
2. Clogged pores - the potential to clog pores which can lead to the development of blackheads and whiteheads, particularly in individuals prone to acne or with oily skin.
3. Dryness - silica is known for its absorbent properties. While this can be beneficial for controlling excess oil on the skin, it may also absorb natural oils, leading to dryness. Silica degrades glutathione leading to oxidative stress/aging.

Phthalates

Phthalates are found in a variety of consumer products, including cosmetics, fragrances, and personal care items. They are known to be endocrine disruptors, which can interfere with reproductive and developmental health.  Phthalates are pervasive in the environment – they can leach or migrate from products into the air, food, or other substances they come into contact with, causing concerns about unintentional exposure through inhalation, ingestion, or skin absorption.  

Additionally, phthalates can accumulate in the human body over time.  The EU has restricted the use of certain phthalates in cosmetics and toys due to health risks.

Phthalates linked with reproductive defects, miscarriages, and allergies.

Petrolatum

Petrolatum is a complex mixture of hydrocarbons derived from the distillation of petroleum. The hydrocarbons that make up petrolatum belong to the methane family. Petrolatum is often used in personal care products as a moisturizing and skin protecting agent. Though it has been deemed generally safe in the US, EU countries have classified it as a carcinogen and have restricted its use in cosmetics.

• Petrolatum is sometimes not fully refined, which can leave it contaminated with toxic chemicals called polycyclic aromatic hydrocarbons.

Many PAHs have toxic, mutagenic and/or carcinogenic properties.

Parabens

Parabens are man-made chemicals used as preservatives in cosmetics. Often multiple parabens are used in a single product. In cell studies, parabens have been found to bind to estrogen receptors.

• Studies demonstrate that at sufficient concentrations, parabens can increase cell proliferation in human breast cancer MCF-7 cells, which are often used as a sensitive measure of estrogenic activity.

Endocrine toxicity, absorption, esterase and human exposure.

Parfums

The chemistry of perfume is generally comprised of: denatured ethanol (C2H6O), essence or fragrance, fixative, propylene glycol (C3H8O2) and distilled water (H20). A few of the most common perfume components are benzyl alcohol, acetone, ethanol, ethyl acetate, benzaldehyde, formaldehyde, and methylene chloride.

• Fragrance in skin care is known to cause redness, itching, hives, and sensitivities such as watery eyes and migraine headaches.

Parfums can irritate skin and eyes and cause migraine headaches.

Formaldehydes

Formaldehyde is commonly used as a preservative in cosmetics and hair care products. It has been known to cause allergic reactions and rashes when in contact with skin. Although concentrations of formaldehyde in personal care products is generally found in low doses, daily product use can contain enough formaldehyde to trigger a reaction in people with formaldehyde sensitivities.

• Formaldehyde is easily absorbed through the skin and eyes, it can cause severe irritation and burns in skin and lead to loss of vision.

Formaldehyde is considered a human carcinogen by the United States National Toxicology Program and the International Agency for Research on Cancer.

Food Allergens

Allergies can manifest in various ways, including skin reactions such as redness, itching, swelling, or hives...our formulas will never include the nine major substances identified as food allergens by the US FDA. These are:

• Milk
• Eggs
• Fish (e.g., bass, flounder, cod)
• Crustacean shellfish (e.g., crab, lobster, shrimp)
• Tree nuts (e.g., almonds, walnuts, pecans)
• Peanuts
• Wheat
• Soybeans
• Sesame
  

Learn more about the 9 Major Food Allergens.

Ethanolamines

Ethanolamines, including compounds such as monoethanolamine (MEA), diethanolamine (DEA), and triethanolamine (TEA), are considered problematic in cosmetics.  They may cause skin irritation or allergic reactions. Ethanolamines can break down into ammonia, which can be irritating to the eyes and respiratory system.  They can react with certain preservatives or other ingredients to form nitrosamines - compounds that have been classified as potential human carcinogens.

The EU has set limits on the concentration of diethanolamine (DEA) in cosmetic products due to their potential health risks.

International Agency for Research on Cancer lists ethanolamines as possible carcinogens.

Drying Alcohols

Drying or Ethyl alcohols, also known as denatured alcohols, have often been used in cosmetics for their preservative effects and as a solvent to increase the solubility of ingredients.

• Increased solubility allows for the formulation to have a smoother, creamier feel.
• The use of these alcohols has been known to cause irritation and can trigger rosacea flare-ups.

Continuous use can disrupt the skin’s protective barrier and make it difficult for skin to naturally retain moisture.

Drying alcohols dry skin making it appear wrinkly and worsen rosacea.

PFAS

PFAS (per-and polyfluoroalkyls) substances are commonly referred to as "lifetime or forever chemicals". Many PFAS, including perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA), are a concern because:

• they do not break down in the environment,
• can move through soils and contaminate drinking water sources,
• build up (bioaccumulate) in fish and wildlife.

Both state and federal regulators are raising awareness of PFAS through media campaigns and developing more stringent rules to limit their use. 

PFAS have been linked with cancer and infertility.

Coal Tar Dyes

Coal tar dyes are formed during the dilution of bituminous coal with hydrocarbon solvents. When coal is diluted with solvents, it produces a variety of vibrant-colored byproducts.

Coal tar dyes contain compounds that are known or suspected to be carcinogens, such as carcinogens, such as benzene, toluene, naphthalene, anthracene, xylene, creosote oils and benzo[a]pyrene, which is a polycyclic aromatic hydrocarbon (National Toxicology Program and the International Agency for Research on Cancer).

• Many coal tar dyes have been banned or restricted by regulatory agencies due to their potential health risks. In both the United States and the European Union, certain coal tar dyes are not allowed for use in cosmetics.
• Coal tar dyes contain heavy metals and chemical solvents and can bioaccumulate. The production and disposal of these dyes may contribute to water pollution and other environmental concerns. 

Coal tar dyes linked with skin cancer and emotional/sleep disturbances.

Benzene

Benzene will never be included in Carmell Cosmetics because it is known to be a human carcinogen. Long-term exposure to benzene has been linked to the development of various cancers, including leukemia and other blood-related cancers. Further impacts include:

• Central Nervous System Effects - High levels of benzene exposure may affect the central nervous system, causing symptoms such as dizziness, headaches, and drowsiness.
• Reproductive Effects - Prolonged exposure to benzene has been associated with reproductive issues, including decreased fertility and developmental abnormalities in unborn children.
• Environmental Impact - Benzene is a significant air pollutant, and its release into the environment can have harmful effects on ecosystems. It contributes to air pollution and can contaminate water and soil.

Benzene is a known human carcinogen.